Remote surgery, digital biomarkers and artificial intelligence, major disruptive changes in digital medicine

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Specialists from different disciplines update on these changes at the Sanitas 2019 Forum, which has dealt with the “Disruption in Personalized Prevention Medicine”.

The application of technology has revolutionized the concept of Medicine as we understand it today, however, we are in the prelude to the next revolution that has already begun to occur in this field. Digital biomarkers, artificial intelligence programs that will allow the development of personalized medicines, and the new channels and services that 5G technology is already allowing focus the disruptive changes that are taking place in the so-called Digital Medicine.

That is one of the great conclusions of the Sanitas Forum 2019, held in Madrid, and at whose inauguration Iñaki Ereño, CEO of Sanitas, has stressed that technology is the great “enabler that allows us to create a collaborative Medicine and seek better Medicines, better diagnoses and better research so that people have longer, healthier and happier lives”.

One of the topics of the first table of the 2019 Health Forum, entitled ‘Disruption in Digital Medicine’, has been the possibilities that 5G technology will allow in the healthcare field, mainly in the field of surgery with remote interventions. The main advantages that it will bring is speed (around 500 - 600 megabytes per second, compared to the 40-70 we have with the 4G); the ability to better use the spectrum that allows more data to be used; the latency or response time that will be less than 5 milliseconds; and the multi-device, that is, the unique devices that can be connected to a single antenna. This last aspect is going to be key in the applications to Medicine, as the mathematician Julia Velasco, director of Network Engineering at Vodafone, has said in her speech.

The services that are demanded now are not very mobile or much data, but they focus on combined services, and that is what 5G will allow us to offer the type of service adapted to each application according to the needs specific requirements. For example, says Velasco, “if you want to do connected surgery, what you need is a lot of data to have good image quality and low latency, if on the contrary what is required is management and monitoring of the medication stock of a hospital I just need many devices, so we can guarantee the quality of that service much better”.

In the case of robotic surgery, what 5G can provide is speed, allowing the extraction of the final computing data and bringing it to the end user to the maximum, being able to transmit an instant communication in 2 milliseconds, Velasco explains. From Vodafone they have participated in a robotic surgery mentoring experience with the Hospital Clínic de Barcelona that allows an expert surgeon to instruct another who is not an expert in that field, in real time, during an operation. The future is in remote surgery that allows a robot to operate a patient receiving the orders of a surgeon located 3,000 kilometers away. A surgery that is already coming true in Asia.

Digital biomarkers

Another of the revolutions in Medicine is being carried out by digital biomarkers. In this field, Juan Carlos Gómez, psychiatrist and world head of Medical Science at Shionogi & Co., has talked about innovation in Neuropsychiatry with portable devices, with everything they are contributing to the world of mental health. He has focused on explaining two areas that are especially relevant for the development of new drugs: digital biomarkers and digital treatments and interventions.

With regard to digital biomarkers, these are based on the use of sensors, passive or active, in mobile devices that the patient carries over on a regular basis. "These biomarkers give us a promise of objective measurements that we have lacked, that are very sensitive, capable of capturing symptomatic fluctuations, with ecological validity and that eliminate biases, both of the patient and the clinician", the psychiatrist illustrates.

Digital biomarkers allow the development of medications much more efficiently, as well as monitoring the evaluation of patients, in a continuous way, in the usual clinical practice. “This is an enormously promising area in the field of treatment of patients in Neuropsychiatry such as those affected by some autisms, schizophrenia”, concludes Gomez.

Digital treatments

The digital treatments of psychiatric conditions are framed in the recommendations of all therapeutic guidelines on the need to, in addition to pharmacological treatment, proceed with a psychotherapeutic or psychosocial approach of patients.

In that field, digital applications can be very beneficial. There are already experiences in development in this field. One of them is a video game for the treatment of attention deficit disorder in children, or a digital therapy to treat people with opioid abuse. "Of course", says Gómez, "they must be digital treatments studied and backed up with scientific literature, so that clinicians can prescribe them safely".

In this context, the psychiatrist has set as an example a study published in Nature Digital Medicine in which 71 health applications in mental illnesses were evaluated. Of these, 81 percent had no scientific attributions, only two of them had controlled studies that supported their results, and a single application had them referenced in a scientific journal.

For his part, Antonio Foncubierta, a member of the research team at IBM Research, has explained some innovative applications of artificial intelligence (AI) in personalized and precision medicine. An artificial intelligence based on data, human-centered, explainable and actionable. Depending on the data, we will have an AI for decision support systems, for digital pathologies, for behavior analysis or for systems biology.